Coenzyme Q10 (CoQ10) is a fat-soluble substance that plays a major role in energy production and antioxidant protection in the body. It is found in the body primarily in its interchangeable ubiquinone and ubiquinol forms.In general, CoQ10 supports mitochondrial energy production, antioxidant activity, cell membrane stabilization, gene expression and apoptosis, and neurological and cardiovascular health.[1,2] Levels of CoQ10 in the body can be affected by a number of factors. Dietary contribution of CoQ10 is minimal and serum levels tend to decline with age or can be reduced due to drug induced nutrient depletion.*[3-5]Synthesis of CoQ10 in the body is regulated by the enzyme HMG-CoAreductase. A variety of factors can inhibit HMG-CoA reductase and hinder CoQ10 production and availability, resulting in a potential increase in oxidative stress and a decrease in energy generation. In the event of reduced production, or drug-induced nutrient depletion, physicians recommend supplementation with CoQ10 to help maintain normal levels in the body.[6,7] Supplementation with CoQ10 has been found to promote favorable outcomes for a targeted group of patients[8] and to improve quality of life, energy levels, neurological health maintenance, exercise tolerance,and muscle comfort for a wide range of individuals.[1,9]
Coenzyme Q10 (CoQ10) is a fat-soluble substance that plays a major role in energy production and antioxidant protection in the body. It is found in the body primarily in its interchangeable ubiquinone and ubiquinol forms.In general, CoQ10 supports mitochondrial energy production, antioxidant activity, cell membrane stabilization, gene expression and apoptosis, and neurological and cardiovascular health.[1,2] Levels of CoQ10 in the body can be affected by a number of factors. Dietary contribution of CoQ10 is minimal and serum levels tend to decline with age or can be reduced due to drug induced nutrient depletion.*[3-5]Synthesis of CoQ10 in the body is regulated by the enzyme HMG-CoAreductase. A variety of factors can inhibit HMG-CoA reductase and hinder CoQ10 production and availability, resulting in a potential increase in oxidative stress and a decrease in energy generation. In the event of reduced production, or drug-induced nutrient depletion, physicians recommend supplementation with CoQ10 to help maintain normal levels in the body.[6,7] Supplementation with CoQ10 has been found to promote favorable outcomes for a targeted group of patients[8] and to improve quality of life, energy levels, neurological health maintenance, exercise tolerance,and muscle comfort for a wide range of individuals.[1,9]
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