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what is Crohn's disease Crohn's disease is a chronic condition characterized by inflammation in the intestinal or GI tract which is also known as the digestive tract since Crohn's disease is a chronic illness it is persistent and will be present throughout a patient's life however patients and physicians can work together to manage the symptoms of this disease the GI tract includes the mouth esophagus stomach small intestine large intestine and anal region Crohn's disease can affect any part of the GI tract but the most common location is the last part of the small intestine which is called the ileum and the first portion of the colon which is also referred to as the large intestine current thinking is that Crohn's disease is a genetic disease caused by abnormal regulation of the immune system the GI tract is frequently confronted with bacteria from our diet and environment many factors